protective effects of hydroxytyrosol on renal ischemia-reperfusion injury in mice

background: renal ischemia reperfusion (ir), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. the aim of this study was to investigate the effects of hydroxytyrosol (ht) on renal ischemia-reperfusion injury in mice. methods: male mice were randomly assigned to three groups (n = 9): (1) sham operated, (2) renal ir (45 min ischemia followed by 24 h reperfusion), or (3) renal ir+ht (5 mg/kg orally for 7 days before renal ir and one hour before ir). animals were sacrificed and the blood and kidney tissue samples were collected for glutathione (gsh) and malondialdehyde (mda) evaluation. results: renal ir injury led to decreases in renal tissue gsh and increases in mda levels compared to sham operated. hydroxytyrosol partially inhibited the ir-induced decrease in gsh activity. in addition, in the renal ir+ht group, mda was increased compared to the renal ir group. conclusions: these findings suggest that ht diminished oxidative stress in renal tissue after renal ir.